Imam Ali (AS) said, Indeed one who disobeys Allah is the enemy of Muhammad (s), even if he is the nearest of his relatives.
الإمامُ عليٌّ (عَلَيهِ الّسَلامُ) : إنَّ عَدُوَّ مُحَمَّد صلَّى اللّه عليه و آله و سلَّم مَنْ عَصَى اللّهَ وإنْ قَرُبَتْ قَرابَتُهُ
Similar narrations
Nahj al-Balāgha #209096. Amīr al-mu’minīn, peace be upon him, said: The persons most attached to the prophets are those who know most what the prophets have...